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7 T mesolimbic connectivity atlas

MesoConnect Atlas Tutorial

Participant-level tractography and along-tract microstructure with the MesoConnect mesolimbic atlas

Start the tutorialDownload the atlas (.zip)
The seven bilateral pathways of the MesoConnect Atlas with their regions of interest
The seven bilateral pathways at the 50% threshold, in the three groupings used by the atlas authors. Figure from the MesoConnect repository (CC BY 4.0).

How the atlas was built →

Corridor-constrained tractography

The warped atlas confines tracking to one corridor. The streamlines are estimated from each participant’s own diffusion data.

Seed, target and atlas warped into one participant, shown in three planes

Registration and region warping

The pathway map and its seed and target regions move from standard space to the participant’s diffusion grid.

The dilated atlas with the seed and target, forming the corridor

Corridor construction

The warped map is dilated and joined to the endpoints, and the region outside it is excluded from tracking.

A cleaned VTA to hippocampus bundle over the mean b = 0 image

Tractography and bundle cleaning

Streamlines are estimated from the participant’s own data, and outlying streamlines are removed.

Neurite density sampled at 100 nodes along the bundle

Along-tract profiling

Each scalar map is sampled at 100 nodes, giving the values that enter the group-level models.

Diffusion data reach this workflow already corrected, from the Diffusion MRI Preprocessing tutorial or an equivalent pipeline.